Experiment 66698
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | ROEVER,C: FERRANTE,J: GONZALEZ,EC: PAL,N: ROETZHEIM,RG:. (2000). COMPARING THE TOXICITY OF DIGOXIN AND DIGITOXIN IN A GERIATRIC POPULATION: SHOULD AN OLD DRUG BE REDISCOVERED?. 93(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | RETROSPECTIVELY THE CHARTS OF ALL PATIENTS MORE THAN 60 YEARS OF AGE WHO WERE CHRONICALLY MANAGED WITH A CARDIAC GLYCOSIDE FROM JANUARY 1995 THROUGH JANUARY 1998 WERE REVIEWED. TOXICITY WAS DEFINED AS ANY CLINICAL EVENT THAT REQUIRED EITHER A REDUCTION IN DOSE OF THE DRUG OR ITS DISCONTINUANCE. TOXICITY OCCURRED AMONG 7.6% OF HOSPITALIZATIONS IN WHICH DIGITOXIN WAS USED, COMPARED WITH 18.3% OF HOSPITALIZATIONS IN WHICH DIGOXIN WAS USED. OVER ALL PATIENTS TAKING DIGITOXIN HAD A LOWER RATE OF TOXICITY THAN THOSE TAKING DIGOXIN. |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |