Experiment 66708
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Citrus paradisi (RUTACEAE) |
| Citation | GUPTA,MC: GARG,SK: BADYAL,D: MALHOTRA,S: BHARGAVA,VK:. (1999). EFFECT OF GRAPEFRUIT JUICE ON THE PHARMACOKINETICS OF THEOPHYLLINE IN HEALTHY MALE VOLUNTEERS.. 21(10) |
| Amount utilized | |
| Compound isolated | |
| Disease | IN AN OPEN CROSSOVER STUDY, THE EFFECT OF GRAPEFRUIT JUICE(GFJ) ON THE PHARMACOKINETICS OF A SINGLE DOSE OF THEOPHYLLINE WAS EXAMINED. PLASMA WAS ASSAYED FOR THEOPHYLLINE BY HPLC AND VARIOUS PHARMACOKINETIC PARAMETERS WERE CALCULATED. ALL VALUES WERE REDUCED EXCEPT TMAX WHICH WAS SLIGHTLY INCREASED. THESE RESULTS INDICATE THAT PATIENTS MAYBE ADVISED NOT TO CONSUME GFJ WHEN TAKING SLOW-RELEASE THEOPHYLLINE AND MONITORING OF PLASMA THEOPHYLLENE LEVELS IN PATIENTS MIGHT BE HELPFUL. |
| Dose amount | 300.0 ML |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | FRUIT JUICE |
| Gender | MALE |