Experiment 667158
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Glycyrrhiza glabra (FABACEAE) |
| Citation | ISHIKAWA,S: KATO,M: TOKUDA,T: MOMOI,H: SEKIJIMA,Y: HIGUCHI,M: YANAGISAWA,N:. (1999). LICORICE-INDUCED HYPOKALEMIC MYOPATHY AND HYPOKAELMIC RENAL TUBULAR DAMAGE IN ANOREXIA NERVOSA.. 26(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | A PATIENT WITH A HISTORY OF ANOREXIA NERVOSA DEVELOPED LICORICE-INDUCED HYPOKALEMIC MYOPATHY. WITH POTASSIUM REPLACEMENT, HIGH CPK BLOOD LEVEL AND MYOPATHIC SIGNS RETURN TO NORMAL. HOWEVER, THE PATIENT MANIFESTED PERSISTENT HYPOKALEMIA AND IMPARIED RENAL FUNCTION TO CONCENTRATE AND ACIDIFY THE URINE. RENAL BIOPSY DEMONSTATED INTENSE DEGENERATION AND VACUOLATION OF TUBULES WITH A NORMAL GLOMERUS WHICH WAS CONSISTENT WITH HYPOKALEMIC NEPHROPATHY. PROLONGED HYPOKALEMIA IN ANOREXIA NERVOSA IS SOMETIMES ATTRIBUTED TO SURREPTITIOUS PURGING OR TAKING DIURETICS, BUT IS NECESSARY TO CHECK THE URINE PH, THE URINE-SPECIFIC GRAVITY, AND THE URINE POTASSIUM LEVEL IN ORDER TO FIND UNDERLYING RENAL DAMAGE EVEN AFTER HYPOKALEMIC MYOPATHY IS TREATED SUCCESSFULLY. |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | ROOT |
| Gender | FEMALE |