Experiment 66724
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Vaccinium myrtillus (ERICACEAE) |
| Citation | CASELLI,L:. (1985). CLINICAL AND ELECTRORETINOGRAPHIC STUDY OF ACTIVE ANTHOCYANOSIDES.. 37() |
| Amount utilized | |
| Compound isolated | |
| Disease | PATIENTS SUFFERING FROM VARIOUS DISEASES OF THE EYES SUCH AS MYOPIA, SIMPLE GLAUCOMA, RETINITIS PIGMENTOSA, DIABETIC AND HYPERTENSIVE RETINOPATHY, WERE TREATED WITH A PHARMACEUTICAL PREPARATION CONTAINING VACCINIUM MYRTILLUS ANTHOCYANOSIDES IN ORDER TO ESTABLISH THE EFFECT OF THESE SUBSTANCES ON RETINA PHOTORECEPTORS AND ON CAPILLARY RESISTANCE. ONE GROUP OF PATIENTS (8 AFFECTED BY MYOPIA, 8 BY SIMPLE GLAUCOMA, 6 BY RETINITIS PIGMENTOSA) RECEIVED A SINGLE ORAL DOSE OF 200 MG OF A DRY HYDROALCOHOLIC EXTRACT OF ANTHOCYANOSIDES AND AN ELECTRO-RETINOGRAM WAS PERFORMED JUST BEFORE AND 90 MINUTES AFTER THE TREATMENT IN ORDER TO ASSESS THE SCOTOPIC SENSITIVITY OF THE RETINA BY DETERMINING THE CRITICAL FUSION FREQUENCY. THE SECOND GROUP OF PATIENTS (6 AFFECTED BY HYPERTENSIVE RETINOPATHY AND 8 BY DIABETIC RETINOPATHY) RECEIVED A DAILY ORAL DOSE OF 250 MG OF A DRY HYDROALCOHOLIC EXTRACT OF ANTHOCYANOSIDES FOR 30 DAYS AND A FLUOROANGIOGRAPHY WAS PERFORMED BEFORE AND AT THE END OF TREATMENT. A SIGNIFICATIVE INCREASE OF THE CRITICAL FUSION FREQUENCY WAS OBTAINED IN PATIENTS AFFECTED BY MYOPIA AND SIMPLE GLAUCOMA SHOWING A POSITIVE EFFECT OF ANTHOCYANOSIDES ON RETNA PHOTORECEPTORS. NO MODIFICATIONS OF RETINA ANGIOGRAPHY WERE OBSERVED IN HYPERTENSIVE AND DIABETIC PATIENTS WHEN COMPARED WITH RESULTS OBTAINED BEFORE THE TREATMENT, I.E. THE CAPILLARY RESISTANCE WAS MANTAINED THROUGHOUT THE TREATMENT. NO CONCLUSIONS CAN BE DRAWN FROM THE RESULTS OBTAINED IN PATIENTS WITH RETINITE PIGMENTOSA. |
| Dose amount | 200.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |
| Gender | GIVEN TO BOTH SEXES |