Experiment 66748
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | VYTHILINGAM,M: ANDERSON,GM: OWENS,MJ: HALASZYNSKI,TM: BREMNER,JD: CARPENTER,LL: HENINGER,GR: NEMEROFF,CB: CHARNEY,DS:. (2000). CEREBROSPINAL FLUID CORTICOTROPIN-RELEASING HORMONE IN HEALTHY HUMANS: EFFECTS OF YOHIMBINE AND NALOXONE.. 85(11) |
| Amount utilized | |
| Compound isolated | |
| Disease | ADULT NORMAL VOLUNTEERS RECEIVED IV YOHIMBINE (N=5; 0.4 UG/KG), NALOXONE (N=4; 125 UG/KG), OR PLACEBO (N=3; 0.9% SALINE). CEREBROSPINAL FLUID (CSF) WAS COLLECTED CONTINUOUSLY, AND CONCENTRATIONS OF CSF CRH, CSF NOREPINEPHRINE (NE), AND PLASMA CORTISOL WERE MEASURED. ADMINISTRATION OF EITHER YOHIMBINE OR NALOXONE CAUSED SIGNIFICANT INCREASES IN PLASMA CORTISOL CONCENTRATIONS OVER TIME. ALTHOUGH YOHIMBINE ROBUSTLY INCREASED CSF NE LEVELS AND APPEARED TO INCREASE CSF CRH LEVELS, THESE EFFECTS WERE NOT SEEN AFTER NALOXONE OR PLACEBO ADMINISTRATION. |
| Dose amount | 0.4 MCG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | KG |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |