Experiment 66765
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | MOLLER,HJ: HEUBERGER,L:. (1989). ANXIOLYTIC POTENCY OF D.L-KAVAIN-RESULTS OF A PLACEBO-CONTROLLED DOUBLE-BLIND STUDY.. 131(37) |
| Amount utilized | |
| Compound isolated | |
| Disease | PLACEBO CONTROLLED, DOUBLE BLIND STUDY INVLOLVING 40 OUT-PATIENTS WITH ANXIETY-RELATED NEUROTIC OR PSYCHOSOMATIC DISTURBANCES. ORAL ADMINISTRATION OF 3 X 200 MG D.L.-KAVAIN DAILY OR THE CORRESPONDING PALCEBO CAPSULES FOLLOWING A ONE WEEK WASHOUT PERIOD. STANDARDIZED ANXIETY RATING SCALE FOR SYMPTOMATOLOGY AND CLINICAL GLOBAL EVALUATION. ACCORDING TO THE TEST SUBJECTS AND THE INVESTIGATING PHYSICANS ASSESSMENT AND ON THE BASIC OF INDIVIDUAL SYMPTOMS THERE WAS A SIGNIFICANT REDUCTION IN ANXIETY SYMPTOMATOLOGY AFTER COMPLETING 2 WEEKS TREATMENT WITH D.L.-KAVAIN COMPARED WITH PLACEBO. ACCORDING TO THE PHYSICANS ASSESSMENT AT THE END OF THE STUDY THERE WERE VERY GOOD AND GOOD IMPROVEMENTS IN 80% OF THE D.L.KAVAIN PATIENTS AND IN 40% OF THE PLACEBO PATIENTS. CLINICALLY RELEVANT EVIDENCE OF THE ANXIOLYTIC POTENCY OF D.L.-KAVAIN. |
| Dose amount | 600.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |