| Disease | THE EFFECT OF PLANT STANOL ESTER ON SERUM CHOLESTEROL IS DOSE-DEPENDENT. HOWEVER, IT IS NOT CLEAR WHAT THE DOSE IS BEYOND WHICH NO ADDITIONAL BENEFIT CAN BE OBTAINED. THEREFORE, WE DETERMINED THE DOSE-RESPONSE RELATIONSHIP FOR SERUM CHOLESTEROL
WITH DIFFERENT DOSES OF PLANT STANOL ESTER IN HYPERCHOLESTEROLEMIC SUBJECTS. IN A SINGLE-BLIND DESIGN EACH 22 MEN OR WOMEN CONSUMED FIVE DIFFERENT DOSES OF PLANT STANOL [TARGET (ACUTE) INTAKE 0(0), 0.8 (0.8), 1.6(1.6), 2.4(2.3), 3.2(3.0) G/DL]
ADDED AS PLANT STANOL ESTERS TO MARGARINE FOR 4 WK. THE ORDER OF DOSE PERIODS WAS RANDOMLY DETERMINED. SERUM TOTAL CHOLESTEROL CONCENTRATION DECREASED (CALCULATED IN REFERENCE TO CONTROL) BY 2.8% (P=0.0384), 6.8% (P<0.001), 10.3% (P<0.001)
AND 11.3% (P<0.001) BY DOSES FROM 0.8 TO 3.2 G. THE RESPECTIVE DECREASES FOR LDL CHOLESTEROL WERE 1.7% (P<0.892), 5.6% (P<0.05), 9.7% (P<0.001) AND 10.4% (P<0.001). ALTHOUGH THE DECREASES WERE NUMERICALLY GREATER WITH 2.4 AND 3.2 G DOSES THAN
WITH 1.6 G DOSE, THESE DIFFERENCE WERE NOT SIGNIFICANT (P-0.054-0.516). SERUM PLANT STANOLS ROSE SLIGHTLY, BUT SIGNIFICANTLY WITH THE DOSE (P<0.001). APOLIPOPROTEIN B CONCENTRATION WAS DECREASED SIGNIFICANTLY ALREADY AT THE DOSE OF 0.8 G (8.7%,
P<0.001). APOLIPOPROTEIN E GENOTYPE DID NOT AFFECT THE LIPID RESPONSES. WE CONCLUDED THAT SIGNIFICANT REDUCTION OF SERUM TOTAL AND LDL CHOLESTEROL CONCENTRATIONS IS REACHED WITH THE 1.6-G STANOL DOSE, AND INCREASING THE DOSE FROM 2.4 TO 3.2 G
DOES NOT PROVIDE CLINICALLY IMPORTANT ADDITIONAL EFFECT. |