Experiment 66822
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Citrus paradisi (RUTACEAE) |
| Citation | VANDEL,P: REGINA,W: REIX,I: VANDEL,S: SECHTER,D: BIZOUARD,P:. (1999). GRAPEFRUIT JUICE AS A CONTRAINDICATION? AN APPROACH IN PSYCHIATRY.. 25(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | FOURTEEN DEPRESSED IN PATIENTS WERE SELECTED FOR THE STUDY. SEVEN OF THEM RECEIVED AMITRIPTYLINE (100 TO 150 MG/D) AND THE SEVEN OTHERS CLOMIPRAMINE (112.5 TO 225 MG/D). TRICYCLIC ANTIDEPRESSANT AND DEMETHYLATED METABOLITE PLASMA LEVELS WERE DETERMINED ON FOUR OCCASIONS. THE FIRST AND SECOND DAY SAMPLES WERE OBTAINED TO DETERMINE THE PLASMA LEVEL INTRAINDIVIDUAL VARIABILITY OF ANTIDEPRESSANTS. ON THE THIRD AND FOURTH DAYS, PLASMA LEVELS WERE DETERMINED AFTER AN ORAL COADMINISTRATION OF THE ANTIDPRESSANT AND 250 ML OF PURE AND FRESH GRAPEFRUIT JUICE. IN THIS GROUP OF PATIENTS, THERE WAS NO METABOLIC INTERACTION BETWEEN AMITRIPTYLINE AND GRAPEFRUIT JUICE. BUT THE MEAN PLASMA LEVELS OF CLOMIPRAMINE AND DESMETHYLCLOMIPRAMINE INCREASED AFTER COADMINISTRATION OF THIS JUICE (+4.5% AND +10.5% RESPECTIVELY). THE AUTHORS CONCLUDED THAT WITH THESE PRELIMINARY RESULTS, THE POTENTIAL CLINICAL RELEVANCE OF THIS INTERACTION CANNOT BE ESTIMATED. |
| Dose amount | 250.0 ML |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | JUICE |