Experiment 66832
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Prunus africana (ROSACEAE) |
| Citation | BARLET,A: ALBRECHT,J: AUBERT,A: FISCHER,M: GROF,F: GROTHUESMANN,HG: MASSON,JC: MAZEMAN,E: MERMON,R: REICHELT,H: SCHONMETZLER,F: SUHLER,A:. (1990). EFFICACY OF PYGEUM AFRICANUM EXTRACT IN THE TREATMENT OF MICTURITIONAL DISORDERS DUE TO BENIGN PROSTATIC HYPERPLASIA. EVALUATION OF OBJECTIVE AND SUBJECTIVE AND SUBJECTIVE PARAMETERS. A MULTICENTRE, RANDOMIZED, DOUBLE-BLIND TRAIL.. 102(22) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE EFFICACY OF AN EXTRACT OF PYGEUM AFRICANUM INT HE TREATMENT OF MICTURITIONAL DISORDERS DUE TO BENIGN PROSTATIC HYPERPLASIA WAS TESTED IN A MULTICENTRE DOUBLE-BLIND TRIAL VIERUS PLACEBO. CAPSULES CONTAINING 50 MG OF PYGEUM AFRICANUM EXTRACT OR PLACEBO WERE ADMINISTERED AT A DOSAGE OF 1 CAPSULSULE IN THE MORNING AND 1 CAPSULE IN THE EVENING OVER A PERIOD OF 60 DAYS. 263 PATIENTS WERE INCLUDED IN THIS STUDY, WHICH WAS CARRIED OUT IN 8 CENTRES IN GERMANY, FRANCE AND AUSTRIA. EVALUATION WAS MAINLY BASED ON QUANTITATIVE PARAMETERS SUCH AS RESIDUAL URINE, UROFLOWMETRY AND THE PRECISE MONITORING OF DIURNAL AND NOCTURNAL POLYKAIURIA. TREATMENT WITH THE PYGEUM AFRICANUM EXTRACT LED TO A MARKED CLINICAL IMPROVEMENT: A COMPARISON OF THE QUANTITATIVE PARAMETERS SHOWED A SIGNIFICANT DIFFERENCE BETWEEN THE PYGEUM AFRICANUM GROUP AND THE PLACEBO GROUP RESPECT TO THERAPEUTIC RESPONSE. THE CHARACTERISTIC SUBJECTIVE SYMPTOMS OF MICTURITIONAL DISORDERS, WHICH WERE EVALUATED BY THE PATIENTS IN A QUALITATIVE MANNER, WERE ALSO SIGNIFICANTLY IMPROVED BY ADMINISTRATION OF PYGEUM AFRICANUM EXTRACT. OVERALL ASSESSMENT AT THE END OF THERAPY, SHOWED THAT MICTURITION IMPOVED IN 66% OF THE PATIENTS TREATED WITH PYGEUM AFRICANUM EXTRACT, AS COMPARED WITH AN IMPROVEMENT OF 31% IN THE PLACEBO GROUP. THE DIFFERENCE WAS SIGNIFICANT AT THE STATITICAL LEVEL OF P<0.001. DURING THERAPY WITH PYGEUM AFRICANUM EXTRACT, GASTROINTESTINAL SIDE EFFECTS OCCURRED IN 5 PATIENTS. TREATMENT WAS DISCONTINUED IN THREE OF THOSE CASES. |
| Dose amount | 100.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | CHCL3 EXT |
| Gender | MALE |