| Disease | A TOTAL OF 165 PATIENTS UNDERGOING ELECTIVE COL9ONOSCOPY WERE RANDOMIZED IN A DOUBLE-BLIND FASHION TO ONE OF THREE ARMS: INTRAVENOUS HYOSCYAMINE (0.25 MG), ORAL HYOSCYAMINE (0.25 MG), OR PLACEBO, ADMINISTERED 20-40 MIN BEFORE COLONSCOPY.
PRIMARY OUTCOME MEASURES INCLUDED INSERTION TIME TO CECUM, PATIENT'S ASSESSMENT OF PAIN, AND PHYSICIAN ASSESSMENT OF SPASM. SECONDARY OUTCOME MEASURS INCLUDED AMOUNT OF ANALGESIC MEDICATIONS USED, TOTAL PROCEDURE TIME, AMOUNT AND TYPE OF
PATHOLOGY VISUALIZED, AND PHYSICIAN ASSESSMENT OF PATIENTS'S PAIN. THIS RANDOMIZED, BOUBLE-BLIND, PALCEBO-CONTROLLED TRIAL DID NOT DEMOSTRATE EFFICACY OF EITHER INTRAVENOUS OR ORAL HYOSCYAMINE AS A PREMEDICATION FRO COLONSCOPY. |