Experiment 66864
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Petroselinum crispum (APIACEAE) |
| Citation | NIELSEN,SE: YOUNG,JF: DANESHVAR,B: LAURIDSEN,ST: KNUTHSEN,P: SANDSTROM,B: DRAGSTED,LO:. (1999). EFFECT OF PARSLEY (PETROSELINUM CRISPUM) INTAKE ON URINARY APIGENIN EXCRETION, BLOOD ANTIOXIDANT ENZYMES AND BIOMARKERS FOR OXIDATIVE STRESS IN HUMAN SUBJECTS.. 81(6) |
| Amount utilized | |
| Compound isolated | |
| Disease | SEVEN MEN AND 7 WOMEN PARTICIPATED IN A RANDOMIZED CROSSOVER TRIAL TO STUDY THE EFFECT OF INTAKE OF PARSLEY, CONTAINING HIGH LEVELS OF THE FLAVONE APIGENIN. THE SUBJECTS RECEIVED A STRICTLY CONTROLLED DIET LOW IN FLAVONES AND OTHER NATURALLY OCCURRING ANTIOXIDANTS DURING THE 2 WKS OF INTERVENTION. THIS BASIC DIET WAS SUPPLEMENTED WITH PARSLEY PROVIDING 3.73-4.49 MG APIGENIN/MJ IN ONE OF THE INTERVENTION WKS. ERYTHROCYTE GLUTATHIONE REDUCTASE AND SUPEROXIDE DISMUTASE ACTIVITIES INCREASED DURING INTERVENTION WITH PARSLEY AS COMPARED WITH THE LEVELS ON THE BASIC DIET, WHEREAS ERYTHROCYTE CATALASE AND GLUTATHIONE PEROXIDASE ACTIVITIES DID NOT CHANGE. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | AERIAL PARTS |
| Gender | GIVEN TO BOTH SEXES |