Experiment 66874
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | JONES,PJ: RAEINI-SARJAZ,M: NTANIOS,FY: VANSTONE,CA: FENG,JY: PARSONS,WE:. (2000). MODULATION OF PLASMA LIPID LEVELS AND CHOLESTEROL KINETICS BY PHYTOSTEROL VERSUS PHYTOSTANOL ESTERS.. 41(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | USING A RANDOMIZED CROSSOVER DOUBLE-BLIND DESIGN, 15 HYPERCHOLESTEROLEMIC SUBJECTS CONSUMED PREPARED DIETS CONTAINING EITHER MARGARINE, MARGARINE WITH PHYTOSTEROL ESTERS(MSE) (1.84 G/D), OR MARGARINE WITH PHYTOSTANOL ESTERS(MSA) (1.84 G/D). PLASMA TOTAL CHOLESTEROL LEVEL AT D 21/22 WAS LOWER FOR MSE BUT NOT MSA VS. M DIETS. PLASMA LOW DENSITY LIPOPROTEIN-CHOLESTEROL MEAN REDUCTIONS AT D 21/22 WERE LARGER FOR MSE AND MSA COMPARED WITH M. CHOLESTEROL ABSORPTION WAS REDUCED FOR MSE AND MSA VS. M, WHILE CHOLESTEROL BIOSYNTHESIS WAS RECIPROCALLY INCREASED FOR MSE AND MSA VS. M. THESE DATA INDICATE THAT PLANT STEROL AND STANOL ESTERS DIFFERENTIALLY LOWER CIRCULATING TOTAL AND LDL CHOLESTEROL LEVELS BY SUPPRESSION OF CHOLESTEROL ABSORPTION IN HYPERCHOLESTEROLEMIC SUBJECTS. |
| Dose amount | 1.84 GM |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Gender | MALE |