Experiment 66878
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | MATTHYS,H: ERHARDT,J: RUHLE,KH:. (1985). OBJEKTIVIERUNG DER WIRKUNG VON ANTITUSSIVA MITTELS TUSSOMETRIE AN PATIENTEN MIT CHRONISCHEM HUSTEN.. 115() |
| Amount utilized | |
| Compound isolated | |
| Disease | PATIENTS RECEIVED THE ACTIVE ANTITUSSIVE DRUGS OR PLACEBO IN A DOUBLE-BLIND, RANDOMIZED CROSS-OVER DESIGN. THE PREPARATIONS WERE ADMINISTERED AT 10 P.M. AND 2 A.M. ON 7 CONSECUTIVE NIGHTS AND NO ANTITUSSIVE WAS GIVEN FOR THE FOLLOWING 20 HRS. COUGH FREQUENCY AND INTENSITY WERE RECORDED FROM 10 P.M. UNTIL 6 A.M. NOSCAPINE, DEXTROMETHORPHAN, DIHYDROCODEINE AND CODEINE (60 MG) SIGNIFICANTLY REDUCED THE COUGH FREQUENCY COMPARED TO PLACEBO. THEY ALSO PRODUCED A GREATER REDUCTION OF COUGH INTENSITY THAN PLACEBO, CODEINE (20 MG) AND CODEINE (30 MG). |
| Dose amount | 60.0 MG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | PERSON |
| Dose expression | DOSE |