Experiment 66910
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | VAN GORKOM,BAP: KARRENBELD,A: VAN DER SLUIS,T: KOUDSTAAL,J: DE VRIES,EGE: KLEIBEUKER,JH:. (2000). INFLUENCE OF A HIGHLY PURIFIED SENNA EXTRACT ON COLONIC EPITHELIUM.. 61(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | ADDITION OF A SENNA EXTRACT TO COLONIC LAVAGE WAS STUDIED IN 184 CONSECUTIVE OUTPATIENTS. FROM 32 RANDOMISED PATIENTS, 15 WITH SENNOSIDES(SEN), 17 WITHOUT(NSEN), BIOPSIES WERE TAKEN. CRYPTS WERE SHORTER IN SEN THAN IN NSEN IN THE TRANSVERSE AND SIGMOID COLON. SENNOSIDES INDUCE ACUTE MASSIVE CELL LOSS PROBABLY BY APOPTOSIS, CAUSING SHORTER CRYPTS, AND INCREASED CELL PROLIFERATION AND INHIBITION OF APOPTOSIS TO RESTORE CELLULARITY. |
| Dose amount | 2.0 MG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | ML |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |