Experiment 66922
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Hypericum perforatum (CLUSIACEAE) |
| Citation | PISCITELLI,SC: BURSTEIN,AH: CHAITT,D: ALFARO,RM: FALLOON,J:. (2000). INDINAVIR CONCENTRATIONS AND ST JOHN'S WORT.. 355(9203) |
| Amount utilized | |
| Compound isolated | |
| Disease | AN OPEN-LABEL STUDY TO ASSESS A POTENTIAL DRUG INTERATION BETWEEN ST. JOHN'S WORT AND INDINAVIR WAS CARRIED OUT IN 8 HEALTHY SUBJECTS. SUBJECTS WERE GIVEN 900 MG OF ST.JOHN'S WORT AND INDINAVIR ON SELECTED DAYS ST.JOHN'S WORT REDUCED THE AREA UNDER THE CURVE OF INDINAVIR BY A MEAN OF 54% AND DECREASED THE EXTRAPOLATED 8-H INDINAVIR TROUGH BY 81% IN HEALTHY VOLUNTEERS. |
| Dose amount | 900.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |
| Gender | MALE |