Experiment 66970
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | TALIANI,MR: AGNELLI,G: NENCI,GG: GIANESE,F:. (1999). DERMATAN SULFATE IN PATIENTS WITH HEPARIN-INDUCED THROMBOCYTOPENIA.. 104(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | PATIENTS WITH THROMBOEMBOLIC DISEASES WHO DEVELOP HEPARIN-INDUCED THROMBOCYTOPENIA (HIT) TYPE II REQUIRE AN ALTERNATIVE ANTICOAGULATION STRATEGY. DERMATAN SULFATE (DS) WAS ADMINISTERED TO FIVE PATIENTS WITH THROMBEOEMBOLIC DISEASES WHO DEVELOPED HIT TYPE II AND SHOWED AN IN VITRO CROSS-REACTIVITY WITH LOW MO. WT. HEPARINS. THE PLATELET COUNT AND THE EXTENSION OF THROMBOSIS WERE MONITORED DURING DS ADMINISTRATION. IN FOUR OF THE FIVE PATIENTS THE PLATELET COUNT RAPIDLY INCREASED AFTER HEPARIN WAS DISCONTINUED AND DS STARTED. |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |