Experiment 67037
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | AHMAD,I: AL-KATIB,AM: BECK,FWJ: MOHAMMAD,RM:. (2000). SEQUENTIAL TREATMENT OF A RESISTANT CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS WITH BRYOSTATIN I FOLLOWED BY 2-CHLORODEOXYADENOSINE: CASE REPORT.. 6(4) |
| Amount utilized | |
| Compound isolated | |
| Disease | A CASE REPORT OF A PATIENT DIAGNOSED WITH RESISTANT CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) AND TREATED SEQUENTIALLY WITH BRYO-1 FOLLOWED BY 2-CDA FOR THREE CYCLE. MOLECULAR AND BIOCHEMICAL PARAMETERS RELATIVE TO THE SEQUENTIAL TREATMENT WITH THESE AGENTS IN VIVO WERE COMPARABLE TO THOSE FOUND IN THE WSU-CLL CELL LINE IN VITRO. RESULT SHOWED THAT SEQUENTIAL TREATMENT WITH BRYO-1 AND 2-CDA CAUSED A SIGNIFICANT REDUCTION IN PERIPHERAL BLOOD LYMPHOCYTES (CCL CELLS) WITH SIMULTANEOUS INDUCTION OF DIFFERENTIATION AND THE INITIATION OF THE BAX: BCL-2 APOTOTIC PATHWAY. |
| Dose amount | 252.0 MCG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | PERSON |
| Dose expression | DOSE |
| Gender | MALE |