Experiment 670614
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | FRICK,RW:. (2000). THREE TREATMENTS FOR CHRONIC VEHNOUS INSUFFICIENCY: ESCIN, HYDROXYETHYLRUTOSIDE, AND DAFLON.. 51(3) |
| Amount utilized | |
| Compound isolated | |
| Disease | ESCIN HAS BEEN SHOWN TO BE SAFE AND EFFECTIVE FOR THE TREATMENT OF CHRONIC VENOUS INSUFFICIENCY. IT ATTENUATES THE DROP IN ADENOSINE TRIPHOSPHATE IN VENOUS ENDOTHELIAL CELLS DURING HYPOXIA. THIS ATTENUATES (1) THE INFLAMMATION RESPONSE, (2) THE ATTRACTION OF NEUTROPHILS, (3) DAMAGE TO THE VEINS AND (4) THE RELEASE OF GROWTH FACTORS. ESCIN REDUCES PERMEABILITY AND FRAGILITY; AND INHIBITS HYALURONIDASE. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |