Experiment 67065

Worktypes

Details

PropertyValue
Pharmacology
Administration routeORAL
OrganismCommiphora mukul (BURSERACEAE)
CitationKUPPURAJAN,K: RAJAGOPALAN,SS: KOTESWARA RAO,T: VIJAYALAKSHMI,AN: DWARAKANATH,C:. (1973). EFFECTS OF GUGGULU (COMMIPHORA MUKUL-ENGL.) ON SERUM LIPIDS IN OBESE SUBJECTS.. 8(4)
Amount utilized
Compound isolated
DiseaseTHE EFFECT OF THE CRUDE DRUG AND A PETROLEUM ETHER EXTRACT IN 120 OBESE PATIENTS WITH HYPERLIPIDEMIA WAS ASSESSED IN A PLACEBO CONTROLLED CLINICAL TRIAL. THE PATIENTS RECEIVED 2 GRAMS OF CRUDE DRUG TWICE DAILY OR A PETROLEUM ETHER FRACTION 0.5 GRAMS THREE TIMES DAILY, A PLACEBO OR CLOBIRATE AS A COMPARISON DRUG FOR 21 DAYS. BOTH THE CRUDE DRUG AND CLOFIBRATE CAUSED A SIGNIFICANT DECREASE IN THE MEAN SERUM CHOLESTEROL LEVELS AFTER 10 DAYS(P<0.01 AND <0.1, RESPECTIVELY). THE PETRO ETHER FRACTION ALSO SIGNIFICANTLY REDUCED SERUM CHOLESTEROL CONCENTRATIONS BY DAY TEN(P<0.05),AS COMPARED WITH PLACEBO.
Dose amount6.0 GM
Number1
Qualitative resultACTIVE
AnimalHUMAN ADULT
Per unitDAY
Dose expressionDOSE
ExtractRESIN