Experiment 67079
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRAVESICULAR |
| Organism | Empty organism |
| Citation | D'HALLEWIN,MA: DE WITTE,PA: WAELKENS,E: MERLEVEDE,W: BAERT,L:. (2000). FLUORESCENCE DETECTION OF FLAT BLADDER CARCINOMA IN SITU AFTER INTRAVESICAL INSTILLATION OF HYPERICIN.. 164(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE STUDY INCLUDED 40 PATIENTS, OF WHOM 26 PRESENTED WITH MACROSCOPIC VISIBLE TUMOR, 9 HAD A POSITIVE CYTOLOGY WITHOUT VISIBLE TUMOR AND 5 UNDERWENT CYTOSCOPY AFTER BACILLUS CALMETTE-GUERIN INSTILLATION (4) OR RADIOTHERAPY(1). WE INSTILLED 40 ML. OF A 8 MU M. SOLUTION OF HYPERICIN INTRAVESICALLY FOR AT LEAST 2 HOURS. FLUORESCENCE EXCITATION WITH BLUE LIGHT WAS EFFECTIVE UP TO 16 HOURS AFTER TERMINATION OF THE INSTILLATION. ALL VISIVLE PAPILLARY TUMORS SHOWED RED FLUORESCNECE. IN ADDITION, 134 FLAT FLUORESCENT AREAS WERE DETECTED.ANALYSIS OF 281 BIOPSIES FROM FLAT BLADDER WALL INDICATED 93% SENSITIVITY AND 98.5% SPECIFICITY FOR DETECTING CARCINOMA IN SITU. VISIBLE LESIONS RESULTING FROM RADIOTHERAPY, CHEMOTHERAPY OR IMM UNOTHERAPY DID NOT SHOW ANY FLUORESCENT SIGNS AND , THEREFORE, DID NOT INDUCE FALSE-POSITIVE READINGS. |
| Dose amount | 8.0 MICROMOLS |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |