Experiment 67086
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Heracleum lanatum (APIACEAE) |
| Citation | RYAN,EA: IMES,S: WALLCE,C: JONES,S:. (2000). HERBAL TEA IN THE TREATMENT OF DIABETES MELLITUS.. 23(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | RANDOMIZED, PLACEBO-CONTROLLED, SINGLE-BLIND STUDY INVOLVING FORTY VOLUNTEERS WITH TYPE 2 DIABETES. AFTER A 1 MONTH "RUN-IN" PERIOD, SUBJECTS DRANK 250 ML/D OF EITHER HERBAL TEA OR A PLACEBO TEA FOR 10 DAYS, AND WERE FOLLOWED UP FOR A FURTHER 4 WKS. A RESPONDER ANALYSIS DEFINED AS A 10% CHANGE IN MEAN BLOOD GLUCOSE LEVELS BASED ON 4 CAPILLARY GLUCOSE READINGS DAILY. SECONDARY END POINTS INCLUDED CHANGES IN HBA-IC, FRUCTOSAMINE AND RESPONSE TO A MEAL CHALLENGE USING ENSURE. THE RESPONDER ANALYSIS SHOWED NO BENEFIT FROM THE HERBAL TEA. FRUCTOSAMINE LEVELS BEFORE AND AFTER TEA THERAPY DECREASED SIGNIFICANTLY IN BOTH STUDY GROUPS. MEAN HBA-IC LEVELS AND INCREMENTAL AREAS UNDER THE GLUCOSE CURVE(AUC) IN THE MEAL CHALLENGE DID NOT CHANGE IN EITHER STUDY GROUP. THESE DATA WERE REANALYSED IN HYPERGLYCEMIC SUBJECTS WITH HBA-IC LEVELS GREATER THAN 120% OF NORMAL. THE RESPONDER ANALYSIS AND HBA-IC LEVELS DID NOT CHANGE IN EITHER GROUP. MEAN (AND STANDARD DEVIATION) FRUCTOSAMINE LEVELS, BEFORE AND AFTER TEA GROUP THAN IN THE PLACEBO TEA GROUP(361[98] VERSUS 338[100] MICROMOL/L, P<0.01 COMPARED WITH 338[60] VERSUS 323[49] MICROMOL/L, P=0.08). |
| Dose amount | 250.0 ML |
| Number | 1 |
| Qualitative result | INACTIVE |
| Animal | HUMAN ADULT |
| Per unit | ML |
| Dose expression | DOSE |
| Extract | INFUSION |
| Gender | GIVEN TO BOTH SEXES |