Experiment 67089
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | EXTERNAL |
| Organism | Empty organism |
| Citation | LEDEZMA,E: MARCANO,K: JORQUERA,A: DE SOUSA,L: PADILLA,M: PULGAR,M: APITZ-CASTRO,R: LA CRUZ,P:. (2000). EFFICACY OF AJOENE IN THE TREATMENT OF TINEA PEDIS:A DOUBLE-BLIND AND COMPARATIVE STUDY WITH TERBINAFINE.. 43(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | COMPARISON OF THE SAFETY AND EFFECTIVENESS OF TWICE-DAILY TOPICAL APPLICATION DURING 1 WK OF 0.6% AND 1% AJOENE AND 1% TERBINAFINE IN THE TREATMENT OF TINEA PEDIS. SEVENTY SOLDIERS FROM THE VENEZUELAN ARMED FORCES, WITH CLINICAL AND MYCOLOGIC DIAGNOSIS OF TINEA PEDIS, WERE INCLUDED IN THIS STUDY. HOWEVER, ONLY 47 WERE AVAILABLE FOR FINAL EVALUATION. THE PATIENTS WERE RANDOMLY DISTRIBUTED INTO 3 TREATMENT GROUPS:0.6% AJOENE, 1% AJOENE, AND 1% TERBINAFINE. CLINICAL FOLLOW-UP SHOWS A RAPID DECLINE IN THE SIGNS AND SYMPTOMS IN ALL GROUPS. EFFICACY OF THE TREATMENTS, MEASURED AS MYCOLOGIC CURE, 60 DAYS AFTER THE END OF THE THERAPY WAS 72% FOR 0.6% AJOENE, 100% FOR 1% AJOENE, AND 94% FOR 1% TERBINAFINE. THIS REPRESENTS THE FIRST DEMONSTRATION OF THE THERAPEUTIC APPLICATION OF AN INHIBITOR OF PHOSPHOLIPID BIOSYNTHESIS IN HUMAN DERMATOPHYTOSIS. |
| Dose amount | 1.0% |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | CONC USED |
| Gender | MALE |