Experiment 67091
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | PETRASSI,C: MASTROMARINO,A: SPARTERA,C:. (2000). PYCNOGENOL IN CHRONIC VENOUS INSUFFICIENCY.. 7(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE AIM OF THE STUDY WAS TO INVESTIGATE THE EFFICACY OF PCYNOGENOL-A FRENCH MARITIME PINE BARK EXTRACT- IN THE TREATMENT OF CHRONIC VEROUS INSUFFICIENCY(CVI). THE STUDY CONSISTED OF A DOUBLE-BLIND PHASE- IN WHICH 20 PATIENTS WERE RECRUITED AND RANDOMLY TREATED WITH PLACEBO OR PYCNOGENOL (100MG 2/3 DAY FOR 2MONTHS)- AND AN OPEN PHASE - IN WHICH OTHER 20 PATIENTS WERE TREATED WITH PYCNOGENOL AT THE SAME DOSE SCHEDULE. IN TOTAL, 40 PATIENTS WERE ENROLLED;30 OF THEM WERE TREATED WITH PYCNOGENOL AND 10 WITH PLACEBO. PYCNOGENOL SIGNIFICANTLY IMPROVED THE LEGS' HEAVINESS AND SUBCUTANEOUS EDEMA;THE VENOUS PRESSURE WAS ALSO SIGNIFICANTLY REDUCED BY THE PYCNOGENOL TREATMENT, THUS ADDING FURTHER CLINICAL EVIDENCE TO ITS THERAPEUTIC EFFICACY IN PATIENTS WITH CVI. PYCNOGENOL WAS EFFECTIVE, PROBABLY BY EITHER STABILIZING THE COLLAGENOUS SUBENDOTHELIAL BASAL MEMBRANE OR SCAVENGING THE FREE RADICALS, OR BY A COMBINATION OF THESE ACTIVITIES. CLINICALLY, CAPILLARY LEAKAGE, PERIVASCULAR INFLAMMATION AND SUBCUTANEOUS EDEMA WERE ALL REDUCED. THE SAFETY OF USE OF PYCNOGENOL IS DEMONSTRATED BY THE LACK OF SIDE EFFECTS OR CHANGES IN BLOOD BIOCHEMISTRY AND HEMATOLOGIC PARAMETERS. PYCNOGENOL CAN BE THEREFORE RECOMMENDED BOTH FOR PREVENTION AND TREATMENT OF CVI AND RELATED VENO-CAPILLARY DISTURBANCES. |
| Dose amount | 300.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |