Experiment 67099
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Salix alba (SALICACEAE) |
| Citation | CHRUBASIK,S: EISENBERG,E: BALAN,E: WEINBERGER,T: LUZZATI,R: CONRADT,C:. (2000). TREATMENT OF LOW BACK PAIN EXACERBATIONS WITH WILLOW BARK EXTRACT: A RANDOMIZED DOUBLE-BLIND STUDY.. 109() |
| Amount utilized | |
| Compound isolated | |
| Disease | A STUDY INVOLVING 210 PATIENTS WITH AN EXACERBATION OF CHRONIC LOW BACK PAIN WHO REPORTED CURRENT PAIN OF 5 OR MORE (OUT OF 10) ON A VISUAL ANALOG SCALE. THEY WERE RANDOMLY ASSIGNED TO RECEIVE AN ORAL WILLOW BARK EXTRACT WITH EITHER 120MG (LOW DOSE) OR 240MG(HIGH DOSE) OF SALICIN,OR PLACEBO,WITH TRAMADOL AS THE SOLE RESCUE MEDICATION, IN A 4-WK BLINDED TRIAL. THE PRINCIPAL OUTCOME MEASURE WAS THE PROPORTION OF PATIENTS WHO WERE PAIN-FREE WITHOUT TRAMADOL FOR AT LEAST 5 DAYS DURING THE FINAL WEEK OF THE STUDY. THE TREATMENT AND PLACEBO GROUPS WERE SIMILAR AT BASELINE IN 114 OF 120 CLINICAL FEATURES. A TOTAL OF 191 PATIENTS COMPLETED THE STUDY. THE NUMBERS OF PAIN-FREE PATIENTS IN THE LAST WEEK OF TREATMENT WERE 27(39%) OF 65 IN THE GROUP RECEIVING HIGH-DOSE EXTRACT, 15(21%) OF 67 IN THE GROUP RECEIVING LOW-DOSE EXTRACT, AND 4(6%) OF 59 IN THE PLACEBO GROUP(P<0.001). THE RESPONSE IN THE HIGH-DOSE GROUP WAS EVIDENT AFTER ONLY 1 WK OF TREATMENT. SIGNIFICANTLY MORE PATIENTS IN THE PLACEBO GROUP REQUIRED TRAMADOL(P<0.001) DURING EACH WEEK OF THE STUDY. ONE PATIENT SUFFERED A SEVERE ALLERGIC REACTION, PERHAPS TO THE EXTRACT. WILLOW BARK EXTRACT MAY BE A USEFUL AND SAFE TREATMENT FOR LOW BACK PAIN. |
| Dose amount | 240.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | TYPE EXT NOT STATED |
| Gender | GIVEN TO BOTH SEXES |