Experiment 67103
Worktypes
Alerts
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Allium sativum (LILIACEAE) |
| Citation | RAHMAN,K: BILLINGTON,D:. (2000). DIETARY SUPPLEMENTATION WITH AGED GARLIC EXTRACT INHIBITS ADP-INDUCED PLATELET AGGREGATION IN HUMANS.. 130(11) |
| Amount utilized | |
| Compound isolated | |
| Disease | A 13-WK STUDY IN NORMOLIPIDEMIC SUBJECTS WHO INGESTED 5ML OF AGED GARLIC EXTRACT(AGE,KYOLIC) PER DAY WAS PERFORMED. BLOOD WAS DRAWN FROM THESE SUBJECTS AT THE BEGINNING AND END OF THE STUDY. AGGREGATION OF PLATELET-RICH PLASMA WAS INDUCED BY ADP;FULL LIPID PROFILES AND LIVER FUNCTION TESTS WERE DETERMINED ON SERUM, AND PLASMA CONCENTRATIONS OF EICOSANOIDS WERE ALSO MEASURED. DIETARY SUPPLEMENTATION WITH AGE SIGNIFICANTLY INHIBITED BOTH THE TOTAL PERCENTAGE AND INITIAL RATE OF PLATELET AGGREGATION AT CONC. OF ADP UP TO 10 MICROMOL/L. THE KM FOR ADP-INDUCED AGGREGATION WERE APPROXIMATELY DOUBLED AFTER SUPPLEMENTATION WITH AGE, WHEREAS THE MAXIMUN RATE OF AGGREGATION WAS UNAFFECTED. NO SIGNIFICANT CHANGES IN PLASMA THROMBOXANE B2 AND 6-KETOPROSTAGLANDIN F1ALPHA CONCENTRATIONS OR SERUM LIPID PROFILES WERE OBSERVED. WE CONCLUDE THAT AGE, WHEN TAKEN AS A DIETARY SUPPLEMENT BY NORMOLIPIDEMIC SUBJECTS, MAY BE BENEFICIAL IN PROTECTING AGAINST CARDIOVASCULAR DISEASE AS A RESULT OF INHIBITING PLATELET AGGREGATION. |
| Dose amount | 5.0 ML |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | ETOH(20%)EXT |
| Gender | GIVEN TO BOTH SEXES |