Experiment 67106
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Phyllanthus amarus (EUPHORBIACEAE) |
| Citation | NARENDRANATHAN,M: REMLA,A: MINI,PC: SATHEESH,P:. (1999). A TRIAL OF PHYLLANTHUS AMARUS IN ACUTE VIRAL HEPATITIS.. 20(4) |
| Amount utilized | |
| Compound isolated | |
| Disease | A RANDOMIZED PLACEBO-CONTROLLED, DOUBLE-BLIND CLINICAL TRIAL ASSESSING THE EFFECT OF PHYLLANTHUS AMARUS IN 57 PATIENTS WITH ACUTE VIRAL HEPATITIS B. THE POWDERS OF THE PLANT WERE GIVEN IN CAPSULE FORM (300MG CAPSULES-3CAPSULES-3CAPSULES THRICE DAILY) AND AN ANTACID POWDER IN SIMILAR CAPSULE WAS USED AS PLACEBO. PERSONS WITH ENCEPHALOPHTHY, PREEXISTING MEDICAL CONDITIONS OR SERUM BILIRUBIN ABOVE 350IU/L WERE EXCLUDED FROM THE STUDY. FIFTY SEVEN PATIENTS WERE RANDOMIZED TO RECEIVE EITHER THE PLACEBO (28 CASES) OR THE DRUG (28 CASES). THE 2 GROUPS WERE COMPARABLE AT THE TIME OF ENTRY. 2 CASES FROM THE PLACEBO AND ONE FROM THE PLACEBO AND ONE FROM THE DRUG GROUP DROPPED OUT OF THE STUDY. THE DURATION OF DISEASE (TIME TAKEN FOR BILIRUBIN TO COME TO BELOW 2MG%) WAS TAKEN AS THE OUTCOME MEASURE. THE DURATION OF DISEASE IN THE 2 GROUPS WAS COMPARED BY COX'S PROPORTIONAL HAZARDS ANALYSIS AFTER ADJUSTING FOR THE VARIABLES THAT INFLUENCE THE DURATION OF JAUNDICE. ONLY INITIAL SERUM BILIRUBIN WAS AN INDEPENDENT PREDICTOR OF DURATION OF JAUNDICE. THE ANALYSIS SHOWED THAT PHYLLANTHUS AMARUS POWDERS DID NOT SIGNIFICANTLY REDUCE THE DURATION OF JAUNDICE IN PERSONS WITH VIRUS B HEPATITIS. |
| Dose amount | 2.7 GM |
| Number | 1 |
| Qualitative result | INACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | PLANT |
| Gender | GIVEN TO BOTH SEXES |