Experiment 67116
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Hypericum perforatum (CLUSIACEAE) |
| Citation | KARLIOVA,M: TREICHEL,U: MALAGO,M: FRILLING,A: GERKEN,G: BROELSCH,CE:. (2000). INTERACTION OF HYPERICUM PERFORATUM (ST.JOHN'S WORT)WITH CYCLOSPORIN A METABOLISM IN A PATIENT AFTER LIVER TRANSPLANTATION.. 33(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | 63-YEAR-OLD PATIENT WHO RECEIVED A LIVER ALLOGRAFT FOR CRYPTOGENIC LIVER CIRRHOSIS IN 1998. THIS PATIENT DEVELOPED SEVERE ACUTE REJECTION 14 MONTHS AFTER TRANSPLANTATION WHICH WAS ASSOCIATED WITH A SUDDEN DROP IN CYCLOSPORIN A LEVELS. TWO WEEKS PREVIOUSLY, HE HAD STARTED TAKING THE HERBAL HYPERICUM PERFORATUM (2X900MG/DAY) FOR INCREASING EPISODES OF DEPRESSION. THE CYCLOSPORIN A DOSAGE LATER HAD TO BE DOUBLED, WHICH CAUSED SOME SIDE EFFECTS. FINALLY, AN ASSESSMENT OF ORAL CYCLOSPORIN A RESOPTION SUGGESTED AN ENHANCED CYCLOSPORIN A METABOLISM. HYPERICUM PERFORATUM WAS STOPPED. BOTH CYCLOSPORIN A DOSAGE AND BLOOD LEVELS IMMEDIATELY RETURNED TO NORMAL. THE LIVER FUNCTION RECOVERED COMPLETELY. IN CONCLUSION, THIS OBSERVATION IS PREVIOUSLY UNDESCRIBED DRUG INTERACTION OF A WIDELY USED HERBAL DRUG.(HYPERICUM PERFORATUM,I.E.ST.JOHN'S WORT) IN A PATIENT AFTER LIVER TRANSPLANTATION. |
| Dose amount | 1.8 GM |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |
| Gender | MALE |