Experiment 67135
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Citrus paradisi (RUTACEAE) |
| Citation | VINCENT,J: HARRIS,SI: FOULDS,G: DOGOLO,LC: WILLAVIZE,S: FRIEDMAN,HL:. (2000). LACK OF EFFECT OF GRAPEFRUIT JUICE ON PHARMACOKINETICS AND PHARMACODYNAMICS OF AMLODIPINE.. 50(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE EFFECTS OF GRAPEFRUIT JUICE ON THE PHARMACOKINETICS AND PHARMACODYNAMICS OF ORAL AND INTRAVENOUS AMLOPIDINE WERE ASSESSED IN 20 HEALTHY MEN IN A PLACEBO-CONTROLLED, OPEN, RANDOMIZED, FOUR-WAY CROSSOVER STUDY USING SINGLE DOSES OF AMLODIPINE 10 MG. FOR 9 DAYS BEGINNING WITH THE DAY OF ADMINISTRATION OF AMLODIPINE, GRAPEFRUIT JUICE (OR WATER CONTROL) WAS GIVEN ONCE DAILY, AND BLOOD SAMPLES, BLOOD PRESSURE AND HEART RATE MEASURES WERE OBTAINED. GRAPEFRUIT JUICE HAS NO APPRECIABLE EFFECT ON AMLODIPINE PHARMACODYNAMICS OR PHARMACOKINETICS. |
| Dose amount | 200.0 ML |
| Number | 1 |
| Qualitative result | INACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | JUICE |
| Gender | MALE |