Experiment 67142
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Aristolochia fangchi (ARISTOLOCHIACEAE) |
| Citation | NORTIER,JL: MARTINEZ,MCM: SCHMEISER,HH: ARLT,VM: BIELER,CA: PETEIN,M: DEPIERREUX,MF: DE PAUW,L: ABRAMOWICZ,D: VEREERSTRAETEN,P: VANHERWEGHEM,JL:. (2000). UROTHELIAL CARCINOMA ASSOCIATED WITH THE USE OF A CHINESE HERB (ARISTOLOCHIA FANGCHI).. 342(23) |
| Amount utilized | |
| Compound isolated | |
| Disease | AMONG 39 PATIENTS WHO AGREED TO UNDERGO PROPHYLACTIC SURGERY,THERE WERE 18 CASES OF UROTHELIAL CARCINOMA (PREVALENCE, 46%;95% CONFIDENCE INTERVAL, 29 TO 62%):17 CASES OF CARCINOMA OF THE URETER, RENAL PELVIS, OR BOTH AND 1 PAPILLARY BLADDER TUMOR. 19 OF THE REMAINING PATIENTS HAD MILD-TO-MODERATE UROTHELIAL DYSPLASIA, AND TWO HAD NORMAL UROTHELIUM. ALL TISSUE SAMPLES ANALYZED CONTAINED ARISTOLOCHIC ACID-RELATED DNA ADDUCTS. THE CUMULATIVE DOSE OF ARISTOLOCHIA WAS A SIGNIFICANT RISK FACTOR FOR UROTHELIAL CARCINOMA, WITH TOTAL DOSES OF MORE THAN 200 G ASSOCIATED WITH A HIGHER RISK OF UROTHELIAL CARCINOMA. THE PREVALENCE OF UROTHELIAL CARCINOMA AMONG PATIENTS WITH END-STAGE CHINESE-HERB NEPHROPHTHY (CAUSED BY ARISTOLOCHIA SPECIES) IS HIGH. |
| Dose amount | 200.0 GM |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | PERSON |
| Dose expression | DOSE |
| Extract | ROOT |
| Gender | GIVEN TO BOTH SEXES |