Experiment 671902
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Citrus paradisi (RUTACEAE) |
| Citation | LUNDAHL,JUE: REGARDH,CG: EDAR,B: JOHNSOON,G:. (1998). THE INTERACTION EFFECT OF GRAPEFRUIT JUICE IS MAXIMAL AFTER THE FIRST GLASS.. 54(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | TWELEVE HEALTHY MALE VOLUNTEERS WERE INCLUDED IN THIS CROSS-OVER TRIAL AND RANDOMLY ALLOCATED TO A DAILY INTAKE OF A 10-MG FELODIPINE EXTENDED RELEASE TABLET WITH WATER OR GRAPEFRUIT JUICE FOR 14 DAYS. SIMILARY TO PREVIOUS SINGLE-DOSE STUDIES THE TREATMENT DURING THE FIRST DAY WITH GRAPEFRUIT JUICE INCREASED THE AUC (+73%) AND CMAX (+138%) OF FELODIPINE WHEN COMPARED WITH THE CONTROL TREATMENT. THE INTERACTION BETWEEN GRAPEFRUIT JUICE AND FELODIPINE APPEARS TO BE ALREADY FULLY DEVELOPED AFTER THE FIRST GLASS OF GRAPEFRUIT JUICE. CONCOMITANT INTAKE OF 10 MG FELODIPINE ER AND THE JUICE IS ASSOCIATED WITH INCREASED HAEMODYNAMIC EFFECTS IN HEALTHY SUBJECTS BOTH AFTER A SINGLE DOSE AND FOLLOWING 14 DAYS OF CONCOMITANT INTAKE. |
| Dose amount | 200.0 ML |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | JUICE |
| Gender | MALE |