Experiment 67312
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Citrus paradisi (RUTACEAE) |
| Citation | KANE,GC: LIPSKY,JJ:. (2000). DRUG-GRAPEFRUIT JUICE INTERACTIONS.. 75(9) |
| Amount utilized | |
| Compound isolated | |
| Disease | GRAPEFRUIT JUICE, A BEVERAGE CONSUMED IN LARGE QUANTITIES BY THE GENERAL POPULATION, IS AN INHIBITOR OF THE INTESTINAL CYTOCHROME P-450 3A4 SYSTEM, WHICH IS RESPONSIBLE FOR THE FIRST-PASS METABOLISM OF MANY MEDICATIONS. THE REVIEW DISCUSSES THE PROPOSED MECHANISMS OF ACTION AND THE MEDICATIONS INVOLVED IN DRUG-GRAPEFRUIT JUICE INTERACTIONS AND ADDRESSES THE CLINICAL IMPLICATIONS OF THESE INTERACTIONS. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | JUICE |
| Gender | GIVEN TO BOTH SEXES |