Experiment 67313
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Hypericum perforatum (CLUSIACEAE) |
| Citation | WOELK,H:. (2000). COMPARISON OF ST JOHN'S WORT AND IMIPRAMINE FOR TREATING DEPRESSION: RANDOMIZED CONTROLLED TRIAL.. 321(7260) |
| Amount utilized | |
| Compound isolated | |
| Disease | A RANDOMIZED, MULTICENTRE, DOUBLE BLIND, PARALLEL GROUP TRIAL OF 324 OUTPATIENTS WITH MILD TO MODERATE DEPRESSION RECEIVED 75 MG IMIPRAMINE TWICE DAILY OR 250 MG HYPERICUM EXTRACT ZE 117 TWICE DAILY FOR 6 WEEKS. MAIN OUTCOME MEASURES: HAMILTON DEPRESSION RATING SCALE, CLINICAL GLOBAL IMPRESSION SCALE, AND PATIENT'S GLOBAL IMPRESSION SCALE. AMONG THE 157 PARTICIPANTS TAKING HYPERICUM MEAN SCORES ON THE HAMILTON DEPRESSION SCALE DECREASED FROM 22.4 AT BASELINE TO 12.00 AT END POINT; AMONG THE 167 PARTICIPANTS TAKING IMIPRAMINE THEY FELL FROM 22.1 TO 12.75. MEAN CLINICAL GLOBAL IMPRESSION SCORES AT END POINT WERE 2.22 OUT OF 7 FOR THE HYPERICUM GROUP AND 2.42 FOR THE IMIPRAMINE GROUP. ON THE 7 POINT SELF ASSESSMENTS OF GLOBAL IMPROVEMENT COMPLETED BY PARTICIPANTS (SCORE OF 1 INDICATING "VERY MUCH IMPROVED" AND 7 INCIDCATING "VERY MUCH DETERIORATED") MEAN SCORES WERE 2.44 IN THE HYPERICUM GROUP AND 2.60 IN THE IMIPRAMINE GROUP. NONE OF THE DIFFERENCES BETWEEN TREATMENT GROUPS WERE SIGNIFICANT. THIS HYPERICUM PERFORATUM EXTRACT IS THERAPEUTICALLY EQUIVALENT TO IMIPRAMINE IN TREATING MILD TO MODERATE DEPRESSION, BUT PATIENTS TOLERATE HYPERICUM BETTER. |
| Dose amount | 500.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |