Experiment 67317
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | BLESA,R:. (2000). GALANTAMINE: THERAPEUTIC EFFECTS BEOND COGNITION.. 11(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | A REVIEW OUTLINING THE POSITIVE AND SUSTAINED EFFECTS OF GALANTAMINE ON PATIENTS' BEHAVIOUR AND DAILY FUNCTIONING AS WELL AS ON CAREGIVER TIME. IN STUDIES OF UP TO 5 MONTHS DURATION, GALANTAMINE-TREATED PATIENTS HAD A SIGNIFICANTLY BETTER OUTCOME ON ADL THAN PLACEBO-TREATED PATIENTS, AND AFTER 12 MONTHS OF TREATMENT WITH GALANTAMINE, PATIENTS' FUNCTIONAL ABILITY WAS PRESERVED. GALANTAMINE ALSO SIGNIFICANTLY BENEFITS BEHAVIOURAL DISTURBANCES IN PATIENTS WITH AD. THESE FUNCTIONAL AND BEHAVIOURAL BENEFITS ARE ASSOCIATED WITH A DECREASE IN THE BURDEN ON CAREGIVERS, AS INDICATED BY A REDUCTION, RELATIVE TO PLACEBO, IN THE TIME SPENT SUPERVISING AND ASSISTING PATIENTS. THESE CLINICAL BENEFITS ARE NOT OFFSET BY DISRUPTION OF PATIENTS' SLEEP, AS HAS BEEN REPORTED WITH OTHER CHOLINERGIC TREATMENTS. |
| Dose amount | VAR |
| Number | 2 |
| Qualitative result | INACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |