Experiment 67319
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | GREEN,A: WILLIAMS,G: NEALE,R: HART,V: LESLIE,D: PARSONS,P: MARKS,GC: GAFFNEY,P: BATTISTUTTA,D: FROST,C: LANG,C: RUSSELL,A:. (1999). DAILY SUNSCREEN APPLICATION AND BETACAROTENE SUPPLEMENTATION IN PREVENTION OF BASAL-CELL AND SQUAMOUS-CELL CARCINOMAS OF THE SKIN: A RANDOMIZED CONTROLLED TRIAL.. 354() |
| Amount utilized | |
| Compound isolated | |
| Disease | IN A RANDOMIZED TRIAL WITH A 2 BY 2 FACTORIAL DESIGN, INDIVIDUALS WERE ASSIGNED TO FOUR TREATMENT GROUPS; DAILY APPLICATION OF A SUN PROTECTION FACTOR 15-PLUS SUNSCREEN TO THE HEAD, NECK, ARMS, AND HANDS, AND BETACAROTENE SUPPLEMENTATION (30 MG PER DAY); SUNSCREEN PLUS PLACEBO TABLETS; BETACAROTENE ONLY; OR PLACEBO ONLY. THE ENDPOINTS AFTER 4.5 YEARS OF FOLLOW-UP WERE THE INCIDENCE OF BASAL-CELL AND SQUAMOUS-CELL CARCINOMAS BOTH IN TERMS OF PEOPLE TREATED FOR NEWLY DIAGNOSED DISEASE AND IN TERMS OF THE NUMBERS OF TUMOURS THAT OCCURRED. 1383 PARTICIPANTS UNDERWENT FULL SKIN EXAMINATION BY A DERMATOLOGIST IN THE FOLLOW-UP PERIOD. 250 OF THEM DEVELOPED 758 NEW SKIN CANCERS DURING THE FOLLOW-UP PERIOD. THERE WERE NO SIGNIFICANT DIFFERENCES IN THE INCIDENCE OF FIRST NEW SKIN CANCERS BETWEEN GROUPS RANDOMLY ASSIGNED DAILY SUNSCREEN AND NO DAILY SUNSCREEN. SIMILARLY, THERE WAS NO SIGNIFICANT DIFFERENCE BETWEEN THE BETACAROTENE AND PLACEBO GROUPS IN INCIDENCE OF EITHER CANCER. IN TERMS OF THE NUMBER OF TUMOURS, THERE WAS NO EFFECT ON INCIDENCE OF BASAL-CELL CARCINOMA BY SUNSCREEN USE OR BY BETACAROTENE. |
| Dose amount | 30.0 MG |
| Number | 1 |
| Qualitative result | INACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |