Experiment 67336
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Citrus paradisi (RUTACEAE) |
| Citation | EBERT,U: OERTEL,R: KIRCH,W:. (2000). INFLUENCE OF GRAPEFRUIT JUICE ON SCOPOLAMINE PHARMACOKINETCS AND PHARMACODYNAMICS IN HEALTHY MALE AND FEMALE SUBJECTS.. 38(11) |
| Amount utilized | |
| Compound isolated | |
| Disease | 14 HEALTHY SUBJECTS (7 MEN AND 7 WOMEN) RECEIVED SCOPOLAMINE 0.5 MG AS INTRAVENOUS INFUSION, AND AS ORAL INGESTION WITH AND WITHOUT GRAPEFRUIT JUICE ON SEPARATE OCCASIONS. SERUM AND URINE SAMPLES WERE ANALYZED. CHANGES IN SUBJECTIVE STATE WERE DETERMINED UP TO 24 HOURS AFTER DRUG ADMINISTRATION. RESULTS: AFTER ORAL ADMINISTRATION, PRETREATMENT WITH GRAPEFRUIT JUICE LED TO A 30% INCREASE IN SYSTEMIC BIOAVAILABILITY OF SCOPOLAMINE (P=0.005) AND A SIGNIFICANT INCREASE IN TIME TO REACH PEAK SERUM CONCENTRATION (TMAX) OF SCOPOLAMINE (P<0.001). PRETREATMENT WITH GRAPEFRUIT JUICE DELAYED THE ABSORPTION AND INCREASED THE BIOAVAILABILITY OF SCOPOLAMINE, WHEREAS ELIMINATION WAS NOT SIGNIFICANTLY AFFECTED. |
| Dose amount | 150.0 ML |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | JUICE |
| Gender | GIVEN TO BOTH SEXES |