Experiment 67338

Worktypes

Details

PropertyValue
Pharmacology
Administration routeORAL
OrganismCitrus sinensis (RUTACEAE)
CitationKUROWSKA,EM: SPENCE,JD: JORDAN,J: WETMORE,S: FREEMAN,DJ: PICHE,LA: SERRATORE,P:. (2000). HDL-CHOLESTEROL-RAISING EFFECT OF ORANGE JUICE IN SUBJECTS WITH HYPERCHOLESTEROLEMIA.. 72(5)
Amount utilized
Compound isolated
DiseaseTHE SAMPLE CONSISTED OF 16 HEALTHY MEN AND 9 HEALTHY WOMEN WITH ELEVATED PLASMA TOTAL AND LDL-CHOLESTEROL AND NORMAL PLASMA TRIACYLGLYCEROL CONCENTRATIONS. PARTICIPANTS INCORPORATED 1, 2, OR 3 CUPS (250 ML EACH) OF ORANGE JUICE SEQUENTIALLY INTO THEIR DIETS, EACH DOSE OVER A PERIOD OF 4 WK. THIS WAS FOLLOWED BY A 5-WK WASHOUT PERIOD. PLASMA LIPID, FOLATE, HOMOCYST(E)INE, AND VITAMIN C (A COMPLIANCE MARKER) CONCENTRATIONS WERE MEASURED AT BASELINE, AFTER EACH TREATMENT, AND AFTER THE WASHOUT PERIOD. CONSUMPTION OF 750 ML BUT NOT OF 250 ML OR 500 ML ORANGE JUICE DAILY INCREASED HDL-CHOLESTEROL CONCENTRATIONS BY 21% (P<0.001), TRIACYLGLYCEROL CONCENTRATIONS BY 30% (FROM 1.56 +/- O.72 TO 2.03 +/- 0.91 MMOL/L; P<0.02), AND FOLATE CONCENTRATIONS BY 18% (P<0.01); DECREASED THE LDL-HDL CHOLESTEROL RATIO BY 16% (P<0.005); AND DID NOT AFFECT HOMOCYST(E)INE CONCENTRATIONS. PLASMA VITAMIN C CONCENTRATIONS INCREASED SIGNIFICANTLY DURING EACH DIETARY PERIOD (2.1, 3.1 AND 3.8 TIMES, RESPECTIVELY). ORANGE JUICE (750 ML/D) IMPROVED BLOOD LIPID PROFILES IN HYPERCHOLESTEROLEMIC SUBJECTS.
Dose amount750.0 ML
Number1
Qualitative resultACTIVE
AnimalHUMAN ADULT
Per unitDAY
Dose expressionDOSE
ExtractJUICE
GenderGIVEN TO BOTH SEXES