Experiment 67349
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Allium sativum (LILIACEAE) |
| Citation | STEINER,M: KHAN,AH: HOLBERT,D: LIN,RIS:. (1996). A DOUBLE-BLIND CROSSOVER STUDY IN MODERATELY HYPERCHOLESTEROLEMIC MEN THAT COMPARED THE EFFECT OF AGED GARLIC EXTRACT AND PLACEBO ADMINISTRATION ON BLOOD LIPIDS.. 64(3) |
| Amount utilized | |
| Compound isolated | |
| Disease | A DOUBLE-BLIND CROSSOVER STUDY COMPARING THE EFFECT OF AGED GARLIC EXTRACT WITH A PLACEBO ON BLOOD LIPIDS WAS PERFORMED IN A GROUP OF 41 MODERATELY HYPERCHOLESTEROLEMIC MEN. AFTER A 4-WK BASELINE PERIOD, DURING WHICH THE SUBJECTS WERE ADVISED TO ADHERE TO A NATIONAL CHOLESTEROL EDUCATION PROGRAM STEP 1 DIET, THEY WERE STARTED ON 7.2 G AGED GARLIC EXTRACT PER DAY OR AN EQUIVALENT AMOUNT OF PLACEBO AS A DIETARY SUPPLEMENT FOR A PERIOD OF 6 MO, THEN SWITCHED TO THE OTHER SUPPLEMENT FOR AN ADDITIONAL 4 MO. BLOOD LIPIDS, BLOOD COUNTS, THYROID AND LIVER FUNCTION MEASURES, BODY WEIGHT, AND BLOOD PRESSURE WERE FOLLOWED. THE MAJOR FINDINGS WERE A REDUCTION IN TOTAL SERUM CHOLESTEROL, LOW-DENSITY-LIPOPROTEIN CHOLESTEROL WAS DECREASED, A DECREASE IN SYSTOLIC BLOOD PRESSURE AND A MODEST REDUCTION OF DIASTOLIC BLOOD PRESSURE IN RESPONSE TO AGED GARLIC EXTRACT. |
| Dose amount | 7.2 GM |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | METHANOL-INSOLUBLE FRACTION |
| Gender | MALE |