Experiment 67396
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Citrus paradisi (RUTACEAE) |
| Citation | GROSS,AS: GOH,YD: ADDISON,RS: SHENFIELD,GM:. (1999). INFLUENCE OF GRAPEFRUIT JUICE ON CISAPRIDE PHARMACOKINETICS.. 65(4) |
| Amount utilized | |
| Compound isolated | |
| Disease | FOURTEEN HEALTHY VOLUNTEERS RECEIVED IN RANDOM ORDER 10 MG CISAPRIDE (PREPULSID) WITH 250 ML WATER OR GRAPEFRUIT JUICE AFTER AN OVERNIGHT FAST. BLOOD SAMPLES WERE TAKEN FOR 25 HOURS AND URINE WAS COLLECTED FOR 36 HOURS AFTER DOSING. PLASMA CONCENTRATIONS OF CISAPRIDE AND URINARY NORCISAPRIDE WERE MEASURED. GRAPEFRUIT JUICE INCREASED CISAPRIDE MAXIMUM MEASURED PLASMA CONCENTRATION AND AREA UNDER THE PLASMA CONCENTRATION-TIME CURVE FROM 0 TO 25 HOURS AND PROLONGED THE TIME TO REACH C MAX. |
| Dose amount | 250.0 ML |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | JUICE |
| Gender | GIVEN TO BOTH SEXES |