Experiment 67397
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | MAS,R: CASTANO,G: ILLNAIT,J: FERNANDEZ,L: FERNANDEZ,J: ALEMAN,C: PONTIGAS,V: LESCAY,M:. (1999). EFFECTS OF POLICOSANOL IN PATIENTS WITH TYPE II HYPERCHOLESTEROLEMIA AND ADDITIONAL CORONARY RISK FACTORS.. 65(4) |
| Amount utilized | |
| Compound isolated | |
| Disease | 437 PATIENTS WERE RANDOMIZED TO RECEIVE, UNDER DOUBLE-BLIND CONDITIONS, 5 MG POLICOSANOL OR PLACEBO ONCE A DAY WITH THE EVENING MEAL FOR 12 WEEKS AND 10 MG POLICOSANOL OR PLACEBO FOR THE NEXT 12 WEEKS. BOTH GROUPS WERE SIMILAR AT RANDOMIZATION. POLICOSANOL (5 AND 10 MG/DAY) SIGNIFICANTLY REDUCED SERUM LOW-DENSITY LIPOPROTEIN CHOLESTEROL AND CHOLESTEROL AND IT SIGNIFICANTLY RAISED HIGH-DENSITY LIPOPROTEIN CHOLESTEROL. TRIGLYCERIDES REMAINED UNCHANGED AFTER THE FIRST 12 WEEKS AND LOWERED SIGNIFICANTLY AT STUDY COMPLETION. |
| Dose amount | 5.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |