Experiment 67427
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Citrus sinensis (RUTACEAE) |
| Citation | EDWARDS,DJ: FITZSIMMONS,ME: SCHUETZ,EG: YASUDA,K: DUCHARME,MP: WARBASSE,LH: WOSTER,PM: SCHUETZ,JD: WATKINS,P:. (1999). 6',7'-DIHYDROXYBERGAMOTTIN IN GRAPEFRUIT JUICE AND SEVILLE ORANGE JUICE: EFFECTS ON CYCLOSPORINE DISPOSITION, ENTEROCYTE CYP3A4, AND P-GLYCOPROTEIN.. 65(3) |
| Amount utilized | |
| Compound isolated | |
| Disease | A RANDOMIZED CROSSOVER STUDY DESIGN WAS USED IN WHICH SUBJECTS RECEIVED A SINGLE ORAL DOSE OF 7.5 MG/KG CYCLOSPORINE WITH WATER, GRAPEFRUIT JUICE, AND SEVILLE ORANGE JUICE. AFTER AN OVERNIGHT FAST, SUBJECTS INGESTED 8 OUNCES OF WATER OR JUICE 30 MINUTES BEFORE ADMINISTRATION OF CYCLOSPORINE AND 3 1/2, 7 1/2, AND 11 1/2 HOURS AFTER THE CYCLOSPORINE DOSE. BLOOD SAMPLES WERE COLLECTED. AREA UNDER THE WHOLE BLOOD CONCENTRATION-TIME CURVE AND PEAK CONCENTRATION OF CYCLOSPORINE WERE INCREASE BY 55% AND 35%, RESPECTIVELY, WITH GRAPEFRUIT JUICE (P<.05). SEVILLE ORANGE JUICE HAD NO INFLUENCE ON CYCLOSPORINE DISPOSITION BUT REDUCED ENTEROCYTE CONCENTRATIONS OF CYP3A4 BY AN AVERAGE OF 40%. 6',7'-DIHYDROXYBERGAMOTTIN DID NOT INHIBIT P-GLYCOPROTEIN AT CONCENTRATIONS UP TO 50 MICROMOL/L. |
| Dose amount | 240.0 ML |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | JUICE |
| Gender | GIVEN TO BOTH SEXES |