Experiment 67439
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Trifolium pratense (FABACEAE) |
| Citation | KNIGHT,DC: HOWES,JB: EDEN,JA:. (1999). THE EFFECT OF PROMENSIL, AN ISOFLAVONE EXTRACT, ON MENOPAUSAL SYMPTOMS.. 2() |
| Amount utilized | |
| Compound isolated | |
| Disease | A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED PROSPECTIVE TRIAL OF 37 POSTMENOPAUSAL WOMEN WITH SYMPTOMS OF ESTROGEN DEFICIENCY WAS PERFORMED OVER A 12-WEEK PERIOD. THE WOMEN WERE RANDOMIZED TO THREE TREATMENT GROUPS: PLACEBO, 40 MG OR 160 MG, DELIVERED IN TABLET FORM. THERE WAS NO SIGNIFICANT DIFFERENCE IN THE INCIDENCE OF FLUSHES BETWEEN THE THREE GROUPS AT TRIAL CONCLUSION. THERE WAS NO DIFFERENCE BETWEEN THE GROUPS IN GREENE MENOPAUSE SYMPTOM SCORES, VAGINAL PH, LEVELS OF FOLLICLE STIMULATING HORMONE(FSH), SEX HORMONE BINDING GLOBULIN(SHBG) OR TOTAL CHOLESTEROL, LIVER FUNCTION OR BLOOD PARAMETERS. A STATISTICALLY SIGNIFICANT INCREASE IN HIGH-DENSITY LIPOPROTEIN (HDL) CHOLESTEROL OF 18.1% (P=0.038) OCCURRED IN THE 40 MG GROUP. A LARGE PLACEBO RESPONSE AND INADVERTENT USE OF DIETARY ISOFLAVONES IN THE PLACEBO GROUP MAY HAVE OBSCURED A SIGNIFICANT CHANGE IN FLUSHING FREQUENCY. PREVIOUS UNCONTROLLED STUDIES CLAIMING A BENEFICIAL EFFECT OF FOODS WITH A HIGH ISOFLAVONE CONTENT ON MENOPAUSAL SYMPTOMS MAY HAVE BEEN CONFOUNDED BY A LARGE PLACEBO RESPONSE. |
| Dose amount | 160.0 MG |
| Number | 2 |
| Qualitative result | INACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | ISOFLAVONE FRACTION |
| Gender | FEMALE |