Experiment 67453
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Citrus paradisi (RUTACEAE) |
| Citation | VARIS,T: KIVISTO,KT: NEUVONEN,PJ:. (2000). GRAPEFRUIT JUICE CAN INCREASE THE PLASMA CONCENTRATIONS OF ORAL METHYLPREDNISOLONE.. 56(6/7) |
| Amount utilized | |
| Compound isolated | |
| Disease | IN A RANDOMISED, TWO-PHASE, CROSS-OVER STUDY, TEN HEALTHY SUBJECTS RECEIVED EITHER 200 ML DOUBLE-STRENGH GRAPEFRUIT JUICE OR WATER THREE TIMES A DAY FOR 2 DAYS. ON DAY 3, 16 MG METHYLPREDNISOLONE WAS GIVEN ORALLY WITH 200 ML GRAPEFRUIT JUICE OR WATER. ADDITIONALLY, 200 ML GRAPEFRUIT JUICE OR WATER WAS INGESTED 0.5 H AND 1.5 H AFTER METHYLPREDNISOLONE ADMINISTRATION. PLASMA CONCENTRATIONS OF METHYLPREDNISOLONE AND CORTISOL WERE DETERMINED. GRAPEFRUIT JUICE INCREASED THE TOTAL AREA UNDER THE PLASMA METHYLPREDNISOLONE CONCENTRATION-TIME CURVE BY 75% AND THE ELIMINATION HALF-LIFE OF METHYLPREDNISOLONE BY 35%. THE PEAK PLASMA CONCENTRATION OF METHYLPREDNISOLONE (CMAX) WAS INCREASED BY 27%. |
| Dose amount | 600.0 ML |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | JUICE |
| Gender | GIVEN TO BOTH SEXES |