Experiment 67469
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Hypericum perforatum (CLUSIACEAE) |
| Citation | DURR,D: STIEGER,B: KULLAK-UBLICK,GA: RENTSCH,KM: STEINERT,HC: MEIER,PJ: FATTINGER,K:. (2000). ST JOHN'S WORT INDUCES INTESTINAL P-GLYCOPROTEIN/MDR1 AND INTESTINAL AND HEPATIC CYP3A4.. 68(6) |
| Amount utilized | |
| Compound isolated | |
| Disease | ADMINISTRATION OF THE EXTRACT TO 8 HEALTHY VOLUNTEERS FOR 14 DAYS RESULTED IN 18% DECREASE IN DIGOXIN EXPOSURE AFTER A SINGLE DOSE (0.5 MG). |
| Dose amount | 900.0 MG |
| Number | 6 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | MEOH(80%) |
| Gender | MALE |