Experiment 67495
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Hypericum perforatum (CLUSIACEAE) |
| Citation | DE MAAT,MMR: HOETELMANS,RMW: MATHOT,RAA: VAN GORP,ECM: MEENHORST,PL: MULDER,JW: BEIJINEN,JH:. (2001). DRUG INTERACTION BETWEEN ST JOHN'S WORT AND NEVIRAPINE.. 15(3) |
| Amount utilized | |
| Compound isolated | |
| Disease | AN INTERACTION BETWEEN ST. JOHN'S WORT AND NEVIRAPINE IN FIVE PATIENTS WITH HIV. NEVIRAPINE PLASMA CONCENTRATIONS WERE CONSISTANTLY LOWER. ORAL CLEARANCE OF NEVIRAPINE WAS SIGNIFICANTLY INCREASED BY 35% WITH CONCOMITANT ADMINISTRATION OF STW. |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |
| Gender | MALE |