Experiment 67506
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRAGASTRIC |
| Organism | Andrographis paniculata (ACANTHACEAE) |
| Citation | PANOSSIAN,A: HOVHANNISYAN,A: MAMIKONYAN,G: ABRAHAMIAN,H: HAMBARDZUMYAN,E: GABRIELIAN,E: GOUKASOVA,G: WIKMAN,G: WAGNER,H:. (2000). PHARMACOKINETIC AND ORAL BIOAVAILABILITY OF ANDROGRAPHOLIDE FROM ANDROGARPHIS PANICULATA FIXED COMBINATION KAN JANG IN RATS AND HUMAN.. 7(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | ANDROGRAPHOLIDE WAS QUICKLY AND ALMOST COMPLETELY ABSORBED INTO THE BLOOD FOLLOWING THE ORAL ADMINISTRATION OF APE AT A DOSE OF 20 MG/KG BODY WT. IN RATS. ITS BIO-AVAILITY, HOWEVER, DECREASED FOUR-FOLD WHEN A 10-TIMES-HIGHER DOSE WAS USED. SINCE A LARGE PART (55%) OF AND IS BOUND TO PLASMA PROTEINS AND ONLY A LIMITED AMOUNT CAN ENTER THE CELL, THE PHARMACOKINETICS OF AND ARE DESCRIBED WELL BY A ONE-COMPARTMENT MODEL. RENAL EXCRETION IS NOT THE MAIN ROUTE FOR ELIMINATING AND. IT IS MOST LIKELY INTENSELY AND DOSE DEPENDENTLY METABOLIZED. |
| Dose amount | 20.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |
| Extract | ETOH(60%)EXT |
| Gender | MALE |