Experiment 67507
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Andrographis paniculata (ACANTHACEAE) |
| Citation | PANOSSIAN,A: HOVHANNISYAN,A: MAMIKONYAN,G: ABRAHAMIAN,H: HAMBARDZUMYAN,E: GABRIELIAN,E: GOUKASOVA,G: WIKMAN,G: WAGNER,H:. (2000). PHARMACOKINETIC AND ORAL BIOAVAILABILITY OF ANDROGRAPHOLIDE FROM ANDROGARPHIS PANICULATA FIXED COMBINATION KAN JANG IN RATS AND HUMAN.. 7(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | FOLLOWING THE ORAL ADMINISTRATION OF FOUR KAN JANG TABLETS ( A SINGLE THERAPEUTIC DOSE, EQUAL TO 20 MG OF AND TO HUMANS, MAXIMUM PLASMA LEVELS APPROXIMATELY 393 MG/ML (APPROX. 1.12 MUM) WERE REACHED AFTER 1.5-2 HOURS, AS QUANTIFIED USING A UV DIODE-ARRAY DETECTION METHOD. HALF-LIFE AND MEAN RESIDENCE TIMES WERE 6.6 AND 10.0 HOURS, RESPECTIVELY. AND PHARMACOKINETICS IN HUMANS ARE EXPLAINED WELL BY AN OPEN TWO-COMPARTMENT MODEL. THE CALCULATED STEADY STATE PLASM CONCENTRATION OF AND FOR MULTIPLE DOSES OF KAN JANG (AFTER THE NORMAL THERAPEUTIC DOSE REGIMEN, 3 X 4 TABLETS/DAY, ABOUT 1 MG AND/KG BODY WT./DAY) WAS APPROXIMATELY 660 NG/ML (APPROX. 1.9 MUM), ENOUGH TO REVEAL ANY ANTI-PAF EFFECT, PARTICULARY AFTER DRUG UPTAKE WHEN THE CONCENTRATION OF AND IN BLOOD IS ABOUT 1342 NG/ML (APPROX. 3.8 MUM, WHILE FOR ANTI-PAF EFFECT EC50-5 MUM). |
| Dose amount | 20.0 MG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | ETOH(60%)EXT |
| Gender | GIVEN TO BOTH SEXES |