Experiment 67510
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Mentha piperita (LAMIACEAE) |
| Citation | MICKLEFIELD,GH: GREVING,I: MAY,B:. (2000). EFFECTS OF PEPPERMINT OIL AND CARAWAY OIL ON GASTRODUODENAL MOTILITY.. 14(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE EFFECT OF ENTERIC-COATED (ENTEROPLANT) AND NON-ENTERIC-COATED PREPARATIONS CONTAINING A PEPPERMINT-CARAWAY OIL COMBINATION WITH 90 MG PEPPERMINT OIL AND 50 MG CARAWAY OIL WAS STUDIED ON GASTRODUODENAL MOTILITY WITH STATIONARY MANOMETRY IN SIX HEALTHY VOLUNTEERS. THE RESULTS SHOWED THAT: (1) BOTH ENTERIC-COATED AND NON-ENTERIC-COATED PREPARATIONS HAVE EFFECTS ON THE MIGRATING MOTOR COMPLEX (MMC); (2) MAINLY A DECREASE IN THE NUMBER OF CONTRACTIONS AND CONTRACTION AMPLITUDES IS SEEN DURING THE VARIOUS PHASES OF THE MMC; (3) NON-ENTERIC-COATED PREPARATIONS HAVE THEIR EFFECTS MAINLY DURING THE FIRST MMC AFTER ADMINISTRATION; (4) ENTERIC-COATED PREPARATIONS HAVE THEIR EFFECTS TEMPORALLY DELAYED DURING THE SECOND MMC AFTER ADMINISTRATION. IN CONCLUSION, ENTERIC-COATED AND NON-ENTERIC-COATED PEPPERMINT-CARAWAY OIL COMBINATIONS ARE SAFE PREPARATIONS, ACTING LOCALLY TO CAUSE SMOOTH MUSCLE RELAXATION. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | ESSENTIAL OIL |
| Gender | GIVEN TO BOTH SEXES |