Experiment 67535
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Citrus paradisi (RUTACEAE) |
| Citation | TASSANEEYAKUL,W: TASSANEEYAKUL,W: VANNAPRASAHT,S: YAMAZOE,Y:. (2000). FORMATION OF OMEPRAZOLE SULPHONE BUT NOT 5-HYDROXYOMEPRAZOLE IS INHIBITED BY GRAPEFRUIT JUICE.. 49(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | THIS WAS A RANDOMIZED CROSSOVER STUDY WITH A 2 WK WASHOUT PERIOD. OMEPRAZOLE (20 MG) WAS TAKEN ORALLYBY 13 HEALTHY VOLUNTEERS WITH EITHER GRAPEFRUIT JUICE OR WATER. SERIAL BLOOD SAMPLES WERE OBTAINED OVER 12H. PLASMA CONCNS. OF OMEPRAZOLE AND ITS MAJOR METABOLITES, 5-HYDROXYOMEPRAZOLE ANDOMEPRAZOLE SULFONE, WERE DETD. BY HPLC. THE PEAK CONCN. (C-MAX) OF OMEPRAZOLE SULFONE WAS REDUCED AFTER ADMINISTRATION OF GRAPEFRUIT JUICE. ADMINISTRATION OF GRAPEFRUIT JUICE DECREASED THE FORMATION OF OMEPRAZOLE SULFONE BUT NOT 5-HYDROXYOMEPRAZOLE. |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | JUICE |