Experiment 67550
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Citrus paradisi (RUTACEAE) |
| Citation | LEE,M: MIN,DI: KU,YM: FLANIGAN,M:. (2001). EFFECT OF GRAPEFRUIT JUICE ON PHARMACOKINETICS OF MICROEMULSION CYCLOSPORINE IN AFRICAN AMERICAN SUBJECTS COMPARED WITH CAUCASIAN SUBJECTS: DOES ETHNIC DIFFERENCE MATTER?.. 41(3) |
| Amount utilized | |
| Compound isolated | |
| Disease | THIS STUDY AIMS TO DETERMINE THE EFFECT OF GRAPEFRUIT JUICE (GJ) ON MICROEMULSION CYCLOSPORINE (CSA) IN 11 AFRICAN AMERICAN SUBJECTS, AND IT WAS COMPARED TO THOSE IN 11 CAUCASIAN SUBJECTS. EACH SUBJECT RECEIVED TWO ORAL DOSES OF CSA WITH WATER (W) OR GJ AS WELL AS IV CSA. REGARDLESS OF RACE, GJ SIGNIFICANTLY INCREASED THE PEAK CONCENTRATION (C-MAX) AND AREA UNDER THE TIME-CURVE (AUC) OF CSA; HOWEVER, THE MAGNITUDE OF GJ EFFECTS WAS DIFFERENT BETWEEN AFRICAN AMERICAN SUBJECTS AND CAUCASIAN SUBJECTS. CONCURRENT ADMINISTRATION OF GJ INCREASES THE BIOAVAILABILITY OF CSA IN AFRICAN AMERICAN SUBJECTS IN GREATER MAGNITUDE COMPARED WITH CAUCASIAN SUBJECTS. |
| Dose amount | 540.0 ML |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | JUICE |