Experiment 67586
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Citrus paradisi (RUTACEAE) |
| Citation | LEE,M: MIN,DI:. (2001). DETERMINATION OF SILDENAFIL CITRATE IN PLASMA BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY AND A CASE FOR THE POTENTIAL INTERACTION OF GRAPEFRUIT JUICE WITH SILDENAFIL CITRATE.. 23(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | A CASE OF POTENTIAL INTERACTION OF GRAPEFRUIT JUICE WITH SILDENAFIL CITRATE IS PRESENTED. THE PEAKS OF SILDENAFIL (MEASURED AS SILDENAFIL SALT) AND INTERNAL STANDARD WERE IDENTIFIED WITH AN ULTRAVIOLET DETECTOR AT 230 NM AND DETECTION LIMIT AT 10 NG/ML. IN A SINGLE ELDERLY MALE PATIENT, GRAPEFRUIT JUICE INCREASED THE C-MAX OF SILDENAFIL BY 42% (1067.7 NG/ML TO 1517.0 NG/ML) ALTHOUGH AUC WAS NOT SIGNIFICANTLY ALTERED (4082.9 NG.H/ML TO 4171.9 NG.H/ML) BY GRAPEFRUIT JUICE. SILDENAFIL COULD BE DETERMINED IN A SIMPLE AND RELIABLE METHOD USING HPLC WITH LIQUID EXTRACTION. THIS CASE INDICATED THAT GRAPEFRUIT JUICE MIGHT INCREASE THE C-MAX OF SILDENAFIL WITHOUT SIGNIFICANT CHANGE IN AUC. A FURTHER STUDY WITH AN APPROPRIATE NUMBER OF SUBJECTS IS NEEDED BEFORE DETERMINING THE DEGREE OF INTERACTION BETWEEN GRAPEFRUIT JUICE AND SILDENAFIL. |
| Number | 1 |
| Qualitative result | EQUIVOCAL |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | JUICE |
| Gender | MALE |